Multiple rounds of gunfire erupted in the city's South Ward sending police rushing to the scene shortly before 6:15 p.m.
Police responded to shots fired reports in the 20's block of Parkhurst Street where they found at least two victims struck by gunfire at that location.
EMS transported the victims to University Hospital in unknown conditions.
Police caught up with the vehicle that was involved in the shooting and gave pursuit when the suspects vehicle crash on Parkhurst Street and Pennsylvania Ave.
Officers chased the suspects on foot, making the arrest in the 30's block of Garden Street. A weapon has been recovered.
There were several crimes scenes established including South Street and Orchard Street where police found a vehicle penetrated by gunfire.